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BB40188: Protein synthesis, folding and turnover

Academic Year: 2018/9
Owning Department/School: Department of Biology & Biochemistry
Credits: 6      [equivalent to 12 CATS credits]
Notional Study Hours: 120
Level: Masters UG & PG (FHEQ level 7)
Period:
Semester 1
Assessment Summary: CW 20%, EX 80%
Assessment Detail:
  • Coursework (CW 20%)
  • Examination (EX 80%)
Supplementary Assessment:
BB40188 Re-assessment coursework (where allowed by programme regulations)
Requisites:
Description: Aims:
To introduce the process of transcription in prokaryotes.
To provide an understanding of ribosome structure and mRNA translation in both prokaryotes and eukaryotes.
To advance knowledge of protein folding and the intracellular pathways of folding and post-translational modification.
To provide an in-depth understanding of the various pathways of intracellular and extracellular protein turnover.
To provide students with a critical and integrated overview of the key processes controlling the production and turnover of cellular proteins, informed by current research.

Learning Outcomes:
After taking this course the student should be able to:
* demonstrate knowledge of how bacterial gene expression is regulated at the transcriptional level and the process of translation;
* critically evaluate our current understanding of the processes involved in protein folding;
* demonstrate a thorough understanding of the pathways involved in protein turnover, and analyse its significance in cellular processes;
* analyse the strengths and limitations for current predictive methods for protein structure.

Skills:
Learning and studying T/F/A, Written communication T/F/A, Information handling & retrieval T/F/A, Working independently T/F.

Content:
Prokaryotic transcription
Translation
Protein Folding
Posttranslational modification
Protein Turnover
Computational approaches to the prediction of protein folding (practical).
Programme availability:

BB40188 is Optional on the following programmes:

Department of Biology & Biochemistry
  • RSBB-AFM19 : Integrated PhD Postgenomic Biosciences (Protein Structure & Function)
  • TSBB-AFM19 : MRes Protein Structure and Function
  • TSBB-AFM13 : MSc Protein Structure and Function

Notes:

  • This unit catalogue is applicable for the 2018/19 academic year only. Students continuing their studies into 2019/20 and beyond should not assume that this unit will be available in future years in the format displayed here for 2018/19.
  • Programmes and units are subject to change in accordance with normal University procedures.
  • Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
  • Undergraduates: .
  • Postgraduates: .